“Our findings indicate the offspring of women who took metformin for PCOS during pregnancy are more likely to meet the criteria for obesity or overweight than children whose mothers were given a placebo during pregnancy,” said the study’s first author, Liv Guro Engen Hanem, M.D., of the Norwegian University of Science and Technology in Trondheim, Norway. “The results were surprising, since limited past research in this area had suggested metformin would have a protective effect on the children’s metabolic health.”
The researchers invited parents of 292 children who participated in two previous randomized clinical trials to be part of this study. In the previous trials, pregnant women with PCOS were assigned to take either metformin or a placebo during pregnancy. The researchers wound up reviewing body mass index (BMI) and other measurements for 161 children born following the two earlier studies.
“Few studies have examined the long-term health of children born to women with PCOS who took metformin,” Hanem said. “Our findings indicate more research is needed to determine its effects on children who were exposed in the womb.”
Ref : https://www.endocrine.org/news-room/2018/diabetes-drug-use-during-pregnancy-linked-to-childs-weight